The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

Gustavo Martínez, Renata M. Pereira, Tarmo Äijö, +13

Immunity

Transcriptional RegulationSignal TransductionCell RegulationAdaptive Immune SystemImmunology +7

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

Matteo Ligorio, Srinjoy Sil, Jose Malagon-Lopez, +45

Cell

Pancreatic CancerBiological MicroenvironmentsMedicineRadiation OncologyTumor Microenvironment +1

CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

Mauro Di Pilato, Raphael Kfuri‐Rubens, Jasper N. Pruessmann, +18

Cell

Tumor BiologyCancer ImmunosurveillanceT CellsMedicineImmunology +7

HIV-infected T cells are migratory vehicles for viral dissemination

Thomas T. Murooka, Maud Déruaz, Francesco Marangoni, +6

Nature

Hiv-infected T CellsHuman RetrovirusImmunologyViral DynamicVirology +3

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

Christian Bauer, Edward Y. Kim, Francesco Marangoni, +3

Journal of Clinical Investigation

T-regulatory CellImmunologyRegulatory T CellsImmune Cell TherapyImmunotherapy +16

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy

Mauro Di Pilato, Edward Y. Kim, Bruno L. Cadilha, +14

Nature

Cancer ImmunosurveillanceT-regulatory CellImmunologyRegulatory T CellsImmune Checkpoint Inhibitor +8

Migratory DCs activate TGF-β to precondition naïve CD8 ⁺ T cells for tissue-resident memory fate

V. Mani, Shannon K. Bromley, Tarmo Äijö, +16

Science

WASP regulates suppressor activity of human and murine CD4+CD25+FOXP3+ natural regulatory T cells

Francesco Marangoni, Sara Trifari, Samantha Scaramuzza, +10

The Journal of Experimental Medicine

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Francesco Marangoni, Ademi Zhakyp, Michela Corsini, +10

Cell

Tumor BiologyCancer ImmunosurveillanceSignal TransductionT-regulatory CellTumor Immunity +10

The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells

Francesco Marangoni, Thomas T. Murooka, Teresa Manzo, +4

Immunity

Signal TransductionAutoimmune DiseaseAdaptive Immune SystemT-regulatory CellImmunology +10