LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

Hien Zhao, Neena John, Vedad Delic, +7

Molecular Therapy — Nucleic Acids

Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice

Hayley S. McLoughlin, Lauren R. Moore, Ravi Chopra, +7

Annals of Neurology

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models

Hien Zhao, Sagar Damle, Karli Ikeda-Lee, +10

Journal of Clinical Investigation

ImmunologyPathologyPeripheral NervesPmp22 Antisense OligonucleotidesNeurology +14

Antisense oligonucleotides extend survival of prion-infected mice

Gregory J. Raymond, Hien Zhao, Brent Race, +19

JCI Insight

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

Eric Vallabh Minikel, Hien Zhao, Jason Le, +21

Nucleic Acids Research

Creutzfeldt-jakob DiseasePathologyNeurochemical BiomarkersPrion Protein LoweringExperimental Neuropathology +18

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease

Tracy Cole, Hien Zhao, Timothy J. Collier, +22

JCI Insight

Neurogenomicsα-Synuclein Antisense OligonucleotidesSnca AsosSnca GeneNeurochemical Biomarkers +22

The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration

Paymaan Jafar‐Nejad, Berit Powers, Armand Soriano, +11

Nucleic Acids Research

ImmunologyMolecular BiologyNeurologyAntisense TherapyNeuropathology +15

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes

Zhiyong Liu, Enquan Xu, Hien Zhao, +2

The EMBO Journal

InflammationMolecular ImmunologySignal TransductionCell SignalingImmune Cell Development +9

Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides

Andrew G. Reidenbach, Eric Vallabh Minikel, Hien Zhao, +6

Biomolecules

Suppression of proteolipid protein rescues Pelizaeus–Merzbacher disease

Matthew S. Elitt, Lilianne Barbar, H. Elizabeth Shick, +18

Nature

BiochemistryNatural SciencesPathologyCellular BiochemistryProteolipid Protein +2