WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

Daniela Bakula, Amelie J. Müller, Theresia Zuleger, +9

Nature Communications

Nuclear morphology is a deep learning biomarker of cellular senescence

Indra Heckenbach, Garik V. Mkrtchyan, Michael Ben Ezra, +12

Nature Aging

The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells

Ping Gao, Chantal Bauvy, Sylvie Souquère, +10

Journal of Biological Chemistry

Modulation of intracellular calcium homeostasis blocks autophagosome formation

Nikolai Engedal, Maria Lyngaas Torgersen, Ingrid Jenny Guldvik, +9

Autophagy

MitophagyIntracellular Calcium LevelsApoptosisCytoskeletonEr Stress +16

Atg18 function in autophagy is regulated by specific sites within its β-propeller

Ester Rieter, Fabian P. Vinke, Daniela Bakula, +4

Journal of Cell Science

Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells

Simon G. Pfisterer, Daniela Bakula, Tancred Frickey, +4

Journal of Lipid Research

Aging and drug discovery

Daniela Bakula, Alexander Aliper, Polina Mamoshina, +20

Aging

Artificial IntelligenceLifespan ExtensionDrug RepositioningEngineeringAging +12

Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 β-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition

Anja Gaugel, Daniela Bakula, Anneliese Hoffmann, +1

Journal of Molecular Signaling

Latest advances in aging research and drug discovery

Daniela Bakula, Andrea Ablasser, Adriano Aguzzi, +27

Aging

WIPI <b>β</b>-propellers function as scaffolds for STK11/LKB1-AMPK and AMPK-related kinase signaling in autophagy

Daniela Bakula, Amelie J. Mueller, Tassula Proikas‐Cezanne

Autophagy

MitophagyAmpk-related KinaseCircuit Scaffold FunctionNew InsightsCellular Physiology +14