Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

Ben Hu, Leiping Zeng, Xing‐Lou Yang, +14

PLoS Pathogens

Horseshoe BatsViral EvolutionSars-related CoronavirusesGeneticsPathogenesis +11

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

Timothy R. Abbott, Girija Dhamdhere, Yanxia Liu, +11

Cell

Combat Sars-cov-2ImmunologyVirologyAntiviral StrategyGene Editing +5

Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing

Xiaoshu Xu, Augustine Chemparathy, Leiping Zeng, +4

Molecular Cell

Evolutionary Arms Race between Virus and Host Drives Genetic Diversity in Bat Severe Acute Respiratory Syndrome-Related Coronavirus Spike Genes

Hua Guo, Bingjie Hu, Xing‐Lou Yang, +4

Journal of Virology

Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response

Leiping Zeng, Yu-Tao Gao, Xing‐Yi Ge, +8

Journal of Virology

Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro

Leiping Zeng, Yanxia Liu, Timothy R. Abbott, +24

Nature Communications

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

Madeline J. Lee, Michelle Leong, Arjun Rustagi, +5

Cell Reports

Nsp1-mediated DownregulationViral ImmunityViral PathogenesisImmunologyAntiviral Response +4

IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection

Qian Zhang, Leiping Zeng, Peng Zhou, +4

PLoS ONE

ImmunologyViral PathogenesisInnate ImmunityCrispr/cas9 SystemTranscriptional Regulation +25

Development of CRISPR as a prophylactic strategy to combat novel coronavirus and influenza

Timothy R. Abbott, Girija Dhamdhere, Yanxia Liu, +11

Crispr-cas13-based StrategyEngineeringViral DiagnosticsImmunologyViral Pathogenesis +20

Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection

Jiarui Wang, Mengting Han, Anish R. Roy, +5

Cell Reports Methods