Nigel D. F. Grindley

The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

Victoria Derbyshire, Nigel D. F. Grindley, Caroline Joyce · The EMBO Journal · 1991 · 276 citations · Full text

Biosynthesis, Nucleic Acid Chemistry, Natural Sciences +11

Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.

Andrea Polesky, Thomas A. Steitz, Nigel D. F. Grindley et al. · Journal of Biological Chemistry · 1990 · 260 citations · Full text

Molecular Biology, Escherichia Coli, Klenow Fragment Structure +16

Method for determining whether a gene of Escherichia coli is essential: application to the polA gene

Caroline Joyce, Nigel D. F. Grindley · Journal of Bacteriology · 1984 · 254 citations · Full text

Genetics, Bacteriology, Bacteriophage +16

Conformational transitions in DNA polymerase I revealed by single-molecule FRET

Yusdi Santoso, Catherine M. Joyce, Olga Potapova et al. · Proceedings of the National Academy of Sciences · 2009 · 244 citations · Full text

Conformational Dynamics, Single Molecule Biophysics, Protein Assembly +13

A single side chain prevents <i>Escherichia coli</i> DNA polymerase I (Klenow fragment) from incorporating ribonucleotides

Mekbib Astatke, Kimmie Ng, Nigel D. F. Grindley et al. · Proceedings of the National Academy of Sciences · 1998 · 203 citations · Full text