Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity

Spencer Park, Enda Shevlin, Yogindra Vedvyas, +5

Scientific Reports

CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors

Irene M. Min, Enda Shevlin, Yogindra Vedvyas, +13

Clinical Cancer Research

Longitudinal PET imaging demonstrates biphasic CAR T cell responses in survivors

Yogindra Vedvyas, Enda Shevlin, Marjan Zaman, +13

JCI Insight

Cell TherapyEngineeringOncologic ImagingPet-mriT-regulatory Cell +23

Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy

Yogindra Vedvyas, Jaclyn E. McCloskey, Yanping Yang, +11

Scientific Reports

Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer

Minkyu Jung, Yanping Yang, Jaclyn E. McCloskey, +13

Molecular Therapy — Oncolytics

Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses

Yanping Yang, Jaclyn E. McCloskey, Huan Yang, +9

Cancer Immunology Research

Car T CellsRadiation OncologyCancer ImmunosurveillanceAutoimmune DiseaseImmunology +13

¹⁸F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management

Harikrishna Kommidi, Hua Guo, Fuad Nurili, +7

Journal of Medicinal Chemistry

PD1 Blockade Enhances ICAM1-Directed CAR T Therapeutic Efficacy in Advanced Thyroid Cancer

Katherine D. Gray, Jaclyn E. McCloskey, Yogindra Vedvyas, +15

Clinical Cancer Research

Self-assembled nanoplatform for targeted delivery of chemotherapy agents via affinity-regulated molecular interactions

Spencer Park, Sungkwon Kang, Alexander J. Veach, +4

Biomaterials

NanoparticlesNanomedicineEngineeringPolymer-drug ConjugateTargeted Delivery +8

Validation of MRI quantitative susceptibility mapping of superparamagnetic iron oxide nanoparticles for hyperthermia applications in live subjects

Kofi Deh, Marjan Zaman, Yogindra Vedvyas, +10

Scientific Reports