Julian A. Hudson

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Richard A. Ward, Mark J. Anderton, Paul A. Bethel et al. · Journal of Medicinal Chemistry · 2019 · 75 citations · Full text

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

James S. Scott, Alan M. Birch, Katy J. Brocklehurst et al. · Journal of Medicinal Chemistry · 2012 · 74 citations · Full text

Glycobiology, Chemical Biology, Molecular Recognition +17

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88^L265P Diffuse Large B-Cell Lymphoma

James S. Scott, Sébastien L. Degorce, Rana Anjum et al. · Journal of Medicinal Chemistry · 2017 · 56 citations · Full text

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point

Richard A. Ward, Paul A. Bethel, Calum Cook et al. · Journal of Medicinal Chemistry · 2017 · 52 citations · Full text

Structure-guided Discovery, Selective Inhibitors, Chemical Biology +20

Thermal energy storage for industrial thermal loads and electricity demand side management

Luigi Cirocco, Peter Pudney, Soheila Riahi et al. · Energy Conversion and Management · 2022 · 50 citations

Industrial Thermal Loads, Electrical Engineering, Engineering +12