Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Kari J. Kurppa, Yao Liu, Ciric To, +41

Cancer Cell

Tumor BiologySignaling PathwayCell RegulationMedicineTreatment-induced Tumor Dormancy +8

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

Ciric To, Tyler S. Beyett, Jaebong Jang, +23

Nature Cancer

Therapy-resistant Mutant FormsMedicinePharmacologyAllosteric InhibitorBronchial Neoplasm +7

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

Anni I. Nieminen, Vilja Eskelinen, Heidi M. Haikala, +4

Proceedings of the National Academy of Sciences

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, +22

Nature Communications

ApoptosisImmunologyCell DeathImmunotherapyCancer Biology +17

<i>UBR5</i> Is Coamplified with <i>MYC</i> in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis

Xi Qiao, Ying Liu, Maria Llamazares Prada, +16

Cancer Research

Repression of <scp>SRF</scp> target genes is critical for <scp>M</scp> yc‐dependent apoptosis of epithelial cells

Katrin E. Wiese, Heidi M. Haikala, Björn von Eyß, +6

The EMBO Journal

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationMedicine +8

Myc requires RhoA/SRF to reprogram glutamine metabolism

Heidi M. Haikala, Elsa Marques, Mikko Turunen, +1

Small GTPases

Cancer ResearchGlutamine MetabolismOncogenic MycConserved Rho GtpaseBiochemistry +12

Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of <i>EGFR</i> -mutant lung cancer

Pınar Ö. Eser, Raymond M. Paranal, Jieun Son, +38

Science Translational Medicine

Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment

Bassel Alsaed, Linh Lin, Jieun Son, +25

Nature Communications

Sortilin‐related receptor is a druggable therapeutic target in breast cancer

Hussein Al‐Akhrass, Mika Pietilä, Johanna Lilja, +7

Molecular Oncology