A human endothelial cell-based recycling assay for screening of FcRn targeted molecules

Algirdas Grevys, Jeannette Nilsen, Kine Marita Knudsen Sand, +12

Nature Communications

Engineered LigandsAngiogenesisCell EngineeringFcrn-binding ProteinsSignaling Pathway +13

Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions

Algirdas Grevys, Malin Bern, Stian Foss, +7

The Journal of Immunology

ImmunologyImmune RegulationImmunologic MechanismHuman Igg1Cellular Physiology +18

An intact C-terminal end of albumin is required for its long half-life in humans

Jeannette Nilsen, Esben Trabjerg, Algirdas Grevys, +11

Communications Biology

Human and mouse albumin bind their respective neonatal Fc receptors differently

Jeannette Nilsen, Malin Bern, Kine Marita Knudsen Sand, +4

Scientific Reports

An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics

Malin Bern, Jeannette Nilsen, Mattia Ferrarese, +21

Science Translational Medicine

Interaction with Both Domain I and III of Albumin Is Required for Optimal pH-dependent Binding to the Neonatal Fc Receptor (FcRn)

Kine Marita Knudsen Sand, Malin Bern, Jeannette Nilsen, +7

Journal of Biological Chemistry

Signal TransductionSignaling PathwayCell SignalingReceptor (Biochemistry)Optimal Ph-dependent Binding +8

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Stian Foss, Siri Aastedatter Sakya, Leire Aguinagalde, +22

Nature Communications

Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies

Kine Marita Knudsen Sand, Bjørn Dalhus, Gregory J. Christianson, +8

Journal of Biological Chemistry

TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity

Stian Foss, Ruth Watkinson, Algirdas Grevys, +8

The Journal of Immunology

Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization

Stian Foss, Algirdas Grevys, Kine Marita Knudsen Sand, +6

Journal of Controlled Release

Cell-based Drug DeliveryEngineeringPolymer-drug ConjugateCell TraffickingImmunoengineering +4