A theoretical study of intramolecular hydrogen bonding in ortho-substituted phenols and thiophenols

Stephen W. Dietrich, Eugéne C. Jorgensen, Peter A. Kollman, +1

Journal of the American Chemical Society

Theoretical StudyEngineeringBiochemistryNatural SciencesChemical Bond +10

Crystallography, quantitative structure-activity relationships, (QSAR) and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines

Corwin Hansch, Bruce A. Hathaway, Zongru Guo, +6

Journal of Medicinal Chemistry

Confidence interval estimators for parameters associated with quantitative structure-activity relationships

Stephen W. Dietrich, Nicholas D. Dreyer, Corwin Hansch, +1

Journal of Medicinal Chemistry

Competitive Enzyme InhibitionParameter EstimationChemical AnalysisMedicineEstimation Statistic +13

Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines

Stephen W. Dietrich, Jeffrey M. Blaney, Mark A. Reynolds, +2

Journal of Medicinal Chemistry

E. ColiBioorganic ChemistryAldo-keto ReductaseEscherichia ColiDrug Resistance +16

A model for thyroid hormone-receptor interactions

Tariq A. Andrea, Stephen W. Dietrich, Wallace J. Murray, +3

Journal of Medicinal Chemistry

Molecular BiologyOh Orientation TransMolecular RecognitionThyroid PhysiologyBiophysics +17

Mean geometry of the thiopeptide unit and conformational features of dithiopeptides and polythiopeptides

V. Balaji, Salvatore Profeta, Stephen W. Dietrich

Biochemical and Biophysical Research Communications

BiochemistryProtein FoldingMedicineNatural SciencesMolecular Biology +6

Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in making inferences about the mechanism of resistance and the structure of the enzyme in situ compared with the enzyme in vitro

Eugene A. Coats, Clara S. Genther, Stephen W. Dietrich, +2

Journal of Medicinal Chemistry

Geometry of proline and hydroxyproline I: An analysis of X-ray crystal structure data

V. Balaji, M. Jagannatha Rao, Shashidhar N. Rao, +2

Biochemical and Biophysical Research Communications

X-ray CrystallographyMaterials ScienceCrystal StructureEngineeringX-ray Diffraction +7

Dihydrofolate reductase inhibition by 2,4-diaminotriazines: A structure-activity study

Stephen W. Dietrich, R. Nelson Smith, James Y. Fukunaga, +2

Archives of Biochemistry and Biophysics

Medicinal ChemistryDihydrofolate Reductase InhibitionBiochemistryMedicineNatural Sciences +4

Inhibition of dihydrofolate reductase. 3. 4,6-Diamino-1,2-dihydro-2,2-dimethyl-1-(2-substituted-phenyl)-s-triazine inhibition of bovine liver and mouse tumor enzymes

Ki Hwan Kim, Stephen W. Dietrich, Corwin Hansch, +2

Journal of Medicinal Chemistry