Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion

Jeremy Garb, Anna Lopatina, Aude Bernheim, +7

Nature Microbiology

Host ResponsePathogenesisBacteriophageSir2-dependent Nad+ DepletionMicrobiology +5

Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion

Mindaugas Zaremba, Donata Dakineviciene, Edvardas Golovinas, +15

Nature Microbiology

BiologyProkaryotic SystemMobile Genetic ElementsShort Prokaryotic ArgonautesGenetics +8

CRISPR-Cas9 Editing in Maize: Systematic Evaluation of Off-target Activity and Its Relevance in Crop Improvement

Joshua K. Young, Gina Zastrow‐Hayes, Stéphane Deschamps, +15

Scientific Reports

Activation of Thoeris antiviral system via SIR2 effector filament assembly

Giedrė Tamulaitienė, Dziugas Sabonis, Giedrius Sasnauskas, +7

Nature

Thoeris Antiviral SystemImmunologyMolecular BiologyVirologyAntiviral Response +4

Conversion of the Tetrameric Restriction Endonuclease Bse634I into a Dimer: Oligomeric Structure–Stability–Function Correlations

Mindaugas Zaremba, Giedrius Sasnauskas, Claus Urbanke, +1

Journal of Molecular Biology

BiochemistryNatural SciencesProtein X-ray CrystallographyMolecular BiologyStructure Elucidation +2

Generation of the BfiI Restriction Endonuclease from the Fusion of a DNA Recognition Domain to a Non-specific Nuclease from the Phospholipase D Superfamily

Mindaugas Zaremba, Claus Urbanke, Stephen E. Halford, +1

Journal of Molecular Biology

Protein ExpressionCellular EnzymologyBiochemistryDna Recognition DomainNatural Sciences +5

Antifungal peptides with novel specific inhibitors of glucosamine 6-phosphate synthase.

Sławomir Milewski, Henryk Chmara, Ryszard Andruszkiewicz, +3

PubMed

Antifungal PeptidesClinical MycologyGlucosamine 6-Phosphate SynthaseChemical BiologyDrug Resistance +14

Central base pair flipping and discrimination by PspGI

Roman H. Szczepanowski, Michael A. Carpenter, H. Czapinska, +5

Nucleic Acids Research

A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3′–5′ and 5′–3′ strands by rotating a single active site

Giedrius Sasnauskas, Linas Zakrys, Mindaugas Zaremba, +4

Nucleic Acids Research

Dna AnalysisMolecular BiologyMolecular GeneticsDna NanotechnologyDouble-stranded Dna +17

Nucleotide flipping by restriction enzymes analyzed by 2-aminopurine steady-state fluorescence

Gintautas Tamulaitis, Mindaugas Zaremba, Roman H. Szczepanowski, +2

Nucleic Acids Research