2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands

Silvia Selleri, F. BRUNI, Camilla Costagli, +5

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryDrug TargetMedicineRational Drug Design +6

A Novel Selective GABA_Aα1 Receptor Agonist Displaying Sedative and Anxiolytic-like Properties in Rodents

Silvia Selleri, F. BRUNI, Camilla Costagli, +11

Journal of Medicinal Chemistry

Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: Synthesis, biological evaluation and 3D-QSAR investigation

Silvia Selleri, Paola Gratteri, Camilla Costagli, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryDrug TargetMedicineNatural SciencesRational Drug Design +9

Synthesis and Benzodiazepine Receptor Affinity of Pyrazolo[1,5-<i>a</i>]pyrimidine Derivatives. 3. New 6-(3-Thienyl) Series as α1 Selective Ligands

Silvia Selleri, F. BRUNI, Camilla Costagli, +10

Journal of Medicinal Chemistry

PharmacotherapyHeterocycle ChemistryPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +14

Benzodiazepine Receptor Ligands. 4. Synthesis and Pharmacological Evaluation of 3-Heteroaryl-8-chloropyrazolo[5,1-<i>c</i>][1,2,4]benzotriazine 5-Oxides

A. COSTANZO, Gabriella Guerrini, Giovanna Ciciani, +7

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryDerivatives3-Thiophene 13D +13

Synthesis of new pyrazolo[5,1-c][1,2,4] benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4] triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions

Giovanna Ciciani, Marcella Coronnello, Gabriella Guerrini, +5

Bioorganic & Medicinal Chemistry

HeterocyclicMedicineDrug DiscoveryOrganic ChemistryChemistry +5

Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy

Gabriella Guerrini, A. COSTANZO, Giovanna Ciciani, +8

Bioorganic & Medicinal Chemistry

Molecular PharmacologyDrug TargetPharmaceutical ChemistryMedicineRational Drug Design +8

2-Phenylpyrazolo[1,5-a]pyrimidin-7-ones. A new class of nonsteroidal antiinflammatory drugs devoid of ulcerogenic activity

G. AUZZI, F. BRUNI, Lucia Cecchi, +7

Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)Bioorganic ChemistryAntiulcerogenic PropertiesBiochemistry +12

Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. part 1: study of the structural features for BZR recognition

Silvia Selleri, F. BRUNI, Camilla Costagli, +5

Bioorganic & Medicinal Chemistry

Structural FeaturesCombinatorial ChemistryPart 1Bioorganic ChemistryBiochemistry +9

Reactivity of 1‐(2‐nitrophenyl)‐5‐aminopyrazoles under basic conditions and synthesis of new 3‐, 7‐, and 8‐substituted pyrazolo[5,1‐<i>c</i>][1,2,4]benzotriazine 5‐oxides, as benzodiazepine receptor ligands

A. COSTANZO, Gabriella Guerrini, F. BRUNI, +1

Journal of Heterocyclic Chemistry

DerivativesHeterocyclicPhenyl‐ Onn ‐AzoxyDerivatives 11AMechanism Of Action +8