In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism

Margaret M. Billingsley, Ningqiang Gong, Alvin J. Mukalel, +14

Small

Ionizable Lipid Nanoparticles for <i>In Vivo</i> mRNA Delivery to the Placenta during Pregnancy

Kelsey L. Swingle, Hannah C. Safford, Hannah C. Geisler, +10

Journal of the American Chemical Society

Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines

Sarah J. Shepherd, Xuexiang Han, Alvin J. Mukalel, +10

Proceedings of the National Academy of Sciences

NanoparticlesLnp FormulationsNanotherapeuticsEngineeringLipid Nanoparticles +18

Molecular Mechanisms of Membrane Curvature Sensing by a Disordered Protein

Wade F. Zeno, Ajay S. Thatte, Liping Wang, +3

Journal of the American Chemical Society

Membrane StructureMembrane Curvature SensingProteinlipid InteractionMembrane FormationBiochemistry +11

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

Kelsey L. Swingle, Alex G. Hamilton, Hannah C. Safford, +12

Nature

EmbryologyDevelopmental BiologyMurine Pre-eclampsiaGynecologyMaternal Health +4

Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy

Ann E. Metzloff, Marshall S. Padilla, Ningqiang Gong, +14

Advanced Materials

Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery

Savan K. Patel, Margaret M. Billingsley, Alvin J. Mukalel, +7

Theranostics

EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta

Hannah C. Geisler, Aditi A Ghalsasi, Hannah C Safford, +9

Journal of Controlled Release

NanomedicineNanotherapeuticsEngineeringPlacental DevelopmentDrug Delivery Systems +8

Clathrin senses membrane curvature

Wade F. Zeno, Jacob B. Hochfelder, Ajay S. Thatte, +5

Biophysical Journal

Membrane TransportMembrane CurvatureMembrane BiologyElectrophysiologyMembrane System +2

Structured and intrinsically disordered domains within Amphiphysin1 work together to sense and drive membrane curvature

Wade F. Zeno, Wilton T. Snead, Ajay S. Thatte, +1

Soft Matter

Membrane StructureProteinlipid InteractionMolecular BiologyAmphiphysin1 WorkCytoskeleton +20