Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells

Teresa Coll, Elena Eyre, Ricardo Rodríguez‐Calvo, +5

Journal of Biological Chemistry

Skeletal Muscle CellsFatty Acid PalmitateLipid PeroxidationInsulin SignalingOxidative Stress +16

Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

Laia Salvadó, Teresa Coll, Anna M. Gómèz‐Foix, +4

Diabetologia

InflammationMetabolic SyndromeInsulin ResistanceSkeletal Muscle CellsAmpk-dependent Mechanism +10

SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

Xavier Palomer, M. Silvia Román-Azcona, Javier Pizarro‐Delgado, +12

Signal Transduction and Targeted Therapy

ImmunologySirt3 Knockout MiceEpigeneticsOxidative StressInflammation +18

The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells

David Álvarez-Guardia, Xavier Palomer, Teresa Coll, +5

Cardiovascular Research

TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model

Xavier Palomer, David Álvarez-Guardia, Ricardo Rodríguez‐Calvo, +6

Cardiovascular Research

The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation

Emma Barroso, Ricardo Rodríguez‐Calvo, Lucía Serrano-Marco, +4

Endocrinology

Fatty Acid OxidationHigh-fat DietFatty Liver DiseaseOxidative StressMetabolic Syndrome +17

Palmitate-Mediated Downregulation of Peroxisome Proliferator–Activated Receptor-γ Coactivator 1α in Skeletal Muscle Cells Involves MEK1/2 and Nuclear Factor-κB Activation

Teresa Coll, Mireia Jové, Ricardo Rodríguez‐Calvo, +6

Diabetes

Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2

Ricardo Rodríguez‐Calvo, Lucía Serrano, Teresa Coll, +8

Diabetes

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

Mohammad Zarei, Emma Barroso, Xavier Palomer, +15

Molecular Metabolism

GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

David Aguilar-Recarte, Emma Barroso, Anna Gumà, +6

Cell Reports