Human tumour cathepsin B. Comparison with normal liver cathepsin B

Kamiar Moin, Nancy A. Day, Mansoureh Sameni, +3

Biochemical Journal

PathologyTumour Cathepsin BTumor BiologyOncologyImmunochemistry +17

Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis

Takashi Hirama, Stella M. Lu, Jason G. Kay, +4

Nature Communications

Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization.

Sadiq Hasnain, Takashi Hirama, C. P. Huber, +2

Journal of Biological Chemistry

Protein ChemistryProtein FunctionBiochemistryCathepsin BCathepsin B-catalyzed Hydrolyzes +12

Characterization of recombinant rat cathepsin B and nonglycosylated mutants expressed in yeast. New insights into the pH dependence of cathepsin B-catalyzed hydrolyses.

Sadiq Hasnain, Takashi Hirama, Amy Tam, +1

Journal of Biological Chemistry

Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane

Takashi Hirama, Raibatak Das, Yanbo Yang, +7

Journal of Biological Chemistry

Peptide nucleic acid–locked nucleic acid polymerase chain reaction clamp‐based detection test for gefitinib‐refractory T790M epidermal growth factor receptor mutation

Hitoshi Miyazawa, Tomoaki Tanaka, Yoshiaki Nagai, +15

Cancer Science

Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points

Mehdi Arbabi‐Ghahroudi, Rebecca To, Nathalie Gaudette, +4

Protein Engineering Design and Selection

A model to explain the pH-dependent specificity of cathepsin B-catalysed hydrolyses

H E Khouri, Céline Plouffe, Sadiq Hasnain, +3

Biochemical Journal

Protein ChemistryBiochemistryCathepsin B-catalysed HydrolysesCathepsin BBiocatalysis +13

Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries.

S. Deng, C. Roger MacKenzie, Takashi Hirama, +5

Proceedings of the National Academy of Sciences

GlycobiologyMolecular BiologyCarbohydrate-protein InteractionSense OligonucleotidesAntibody Engineering +20

Disulfide linkage engineering for improving biophysical properties of human VH domains

D. Y. Kim, Hiba Kandalaft, Wen Ding, +6

Protein Engineering Design and Selection

EngineeringDisulfide LinkageMolecular BiologyHuman Vh DomainsAnalytical Ultracentrifugation +20