Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

Gaurav Backliwal, Markus Hildinger, Sébastien Chenuet, +3

Nucleic Acids Research

ImmunologyImmunodominanceMolecular BiologyTransient TransfectionImmunologic Mechanism +25

Mild Hypothermia Improves Transient Gene Expression Yields Several Fold in Chinese Hamster Ovary Cells

Sarah Wulhfard, Stéphanie Tissot, Sophie Bouchet, +4

Biotechnology Progress

Viral ReplicationImmunologyReproductive BiologyCellular PhysiologyOxidative Stress +16

The Antibody-Based Delivery of Interleukin-12 to the Tumor Neovasculature Eradicates Murine Models of Cancer in Combination with Paclitaxel

Nadine Pasche, Sarah Wulhfard, Francesca Pretto, +2

Clinical Cancer Research

Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, +5

Clinical Cancer Research

Valproic acid enhances recombinant mRNA and protein levels in transiently transfected Chinese hamster ovary cells

Sarah Wulhfard, Lucia Baldi, David L. Hacker, +1

Journal of Biotechnology

Valproic Acid EnhancesOocyteDevelopmental BiologyHormonal ReceptorProtein Levels +7

Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

Natalie Müller, Madiha Derouazi, Frédéric Van Tilborgh, +4

Biotechnology Letters

Embryo CultureOocyteCell DivisionGeneticsNon-instrumented Cultivation Systems +7

Cloning and characterization of novel tumor-targeting immunocytokines based on murine IL7

Nadine Pasche, Janine Woytschak, Sarah Wulhfard, +3

Journal of Biotechnology

Cancer ImmunosurveillanceImmunologyTumor ImmunityNovel Tumor-targeting ImmunocytokinesImmunologic Mechanism +7

Antibody Format and Drug Release Rate Determine the Therapeutic Activity of Noninternalizing Antibody–Drug Conjugates

Rémy Gébleux, Sarah Wulhfard, Giulio Casi, +1

Molecular Cancer Therapeutics

ImmunologyTherapeutic ActivitySip FormatImmunotherapyTumor Biology +15

The antibody‐based delivery of interleukin‐12 to solid tumors boosts NK and CD8 ⁺ T cell activity and synergizes with immune checkpoint inhibitors

Emanuele Puca, Philipp Probst, Marco Stringhini, +9

International Journal of Cancer

A Highly Functional Synthetic Phage Display Library Containing over 40 Billion Human Antibody Clones

Marcel Weber, Emil Bujak, Alessia Putelli, +6

PLoS ONE

EngineeringImmunologyBacteriophageMolecular BiologyImmunotherapy +15