Human intervertebral discs harbour a unique microbiome and dysbiosis determines health and disease

Shanmuganathan Rajasekaran, Dilip Chand Raja Soundararajan, Chitraa Tangavel, +7

European Spine Journal

Dysbiosis Determines HealthDysbiosisIntervertebral DiscMicrobiotaPathogenesis +6

ISSLS PRIZE IN CLINICAL SCIENCE 2017: Is infection the possible initiator of disc disease? An insight from proteomic analysis

Shanmuganathan Rajasekaran, Chitraa Tangavel, Siddharth N. Aiyer, +7

European Spine Journal

Degenerative SpineIntervertebral DiscMedicinePossible InitiatorPathogenesis +7

Inflammaging determines health and disease in lumbar discs—evidence from differing proteomic signatures of healthy, aging, and degenerating discs

Shanmuganathan Rajasekaran, Chitraa Tangavel, K. S. Sri Vijay Anand, +7

The Spine Journal

InflammationLumbar SpineIntervertebral DiscDetermines HealthDegenerative Spine +9

Modic changes are associated with activation of intense inflammatory and host defense response pathways – molecular insights from proteomic analysis of human intervertebral discs

Shanmuganathan Rajasekaran, Dilip Chand Raja Soundararajan, Sharon Miracle Nayagam, +7

The Spine Journal

InflammationProteomic TechnologyInflammatory DiseaseIntervertebral DiscMedicine +11

Bacteria in human lumbar discs – subclinical infection or contamination? Metabolomic evidence for colonization, multiplication, and cell-cell cross-talk of bacteria

Shanmuganathan Rajasekaran, Chitraa Tangavel, Gowdaman Vasudevan, +7

The Spine Journal

Medical MicrobiologyBacterial InfectionsMicrobial DiseaseMedicineBacteriology +6

Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma

Shanmuganathan Rajasekaran, Chitraa Tangavel, Dilip Chand Raja Soundararajan, +8

Neurospine

“Are we barking up the wrong tree? Too much emphasis on Cutibacterium acnes and ignoring other pathogens”— a study based on next-generation sequencing of normal and diseased discs

Shanmuganathan Rajasekaran, Gowdaman Vasudevan, Murugesh Easwaran, +8

The Spine Journal

BiologyPathogenic MicrobiologyMicrobial DiseaseMicrobial PathogensWrong Tree +8

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc

Shanmuganathan Rajasekaran, Dilip Chand Raja Soundararajan, Chitraa Tangavel, +7

Asian Spine Journal

Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs

Shanmuganathan Rajasekaran, Dilip Chand Raja Soundararajan, Sharon Miracle Nayagam, +5

Asian Spine Journal

Comparative metagenomic analysis of human intervertebral disc nucleus pulposus and cartilaginous end plates

Shanmuganathan Rajasekaran, Chitraa Tangavel, K. S. Sri Vijay Anand, +6

Frontiers in Cardiovascular Medicine