Glyn Williams

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Steven Howard, Valério Berdini, John A. Boulstridge et al. · Journal of Medicinal Chemistry · 2008 · 329 citations · Full text

Drug Target, Pyrazol-4-yl Urea, Clinical Candidate +18

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Christopher W. Murray, Maria G. Carr, Owen Callaghan et al. · Journal of Medicinal Chemistry · 2010 · 185 citations · Full text

Molecular Docking, High Ligand Efficiency, Medicinal Chemistry +15

Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors

K. E. B. PARKES, Philipp Ermert, Jürg Fässler et al. · Journal of Medicinal Chemistry · 2003 · 141 citations · Full text

Cell Culture, Antiviral Drug, Drug Resistance +16

Probing Hot Spots at Protein−Ligand Binding Sites:  A Fragment-Based Approach Using Biophysical Methods

Alessio Ciulli, Glyn Williams, Alison G. Smith et al. · Journal of Medicinal Chemistry · 2006 · 133 citations · Full text

Exploring Weak Ligand–Protein Interactions by Long‐Lived NMR States: Improved Contrast in Fragment‐Based Drug Screening

Roberto Buratto, Daniele Mammoli, Elisabetta Chiarparin et al. · Angewandte Chemie International Edition · 2014 · 93 citations · Full text