Glyn Williams

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Steven Howard, Valério Berdini, John A. Boulstridge et al. · Journal of Medicinal Chemistry · 2008 · 331 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +14

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Christopher W. Murray, Maria G. Carr, Owen Callaghan et al. · Journal of Medicinal Chemistry · 2010 · 186 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors

K. E. B. PARKES, Philipp Ermert, Jürg Fässler et al. · Journal of Medicinal Chemistry · 2003 · 142 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Probing Hot Spots at Protein−Ligand Binding Sites:  A Fragment-Based Approach Using Biophysical Methods

Alessio Ciulli, Glyn Williams, Alison G. Smith et al. · Journal of Medicinal Chemistry · 2006 · 133 citations · Full text

Life Sciences, Biochemistry, Biophysics +17

Exploring Weak Ligand–Protein Interactions by Long‐Lived NMR States: Improved Contrast in Fragment‐Based Drug Screening

Roberto Buratto, Daniele Mammoli, Elisabetta Chiarparin et al. · Angewandte Chemie International Edition · 2014 · 95 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +17