Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows

Rita Lampignano, Martin H. Neumann, Sabrina Weber, +28

Clinical Chemistry

Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening

Vera Kloten, Birte Becker, Kirsten Winner, +7

Breast Cancer Research

Liquid biopsy in colon cancer: comparison of different circulating DNA extraction systems following absolute quantification of <i>KRAS</i> mutations using Intplex allele-specific PCR

Vera Kloten, Nadine Rüchel, Nadina Ortiz Brüchle, +8

Oncotarget

Technical Evaluation of Commercial Mutation Analysis Platforms and Reference Materials for Liquid Biopsy Profiling

Sabrina Weber, Benjamin Spiegl, Samantha Perakis, +19

Cancers

Dna AnalysisPathologyHigh Throughput SequencingNucleic Acid BiomarkersTumor Biology +21

Multicenter Evaluation of Circulating Plasma MicroRNA Extraction Technologies for the Development of Clinically Feasible Reverse Transcription Quantitative PCR and Next-Generation Sequencing Analytical Work Flows

Vera Kloten, Martin H. Neumann, Francesca Di Pasquale, +16

Clinical Chemistry

Epigenetic inactivation of the novel candidate tumor suppressor gene<i>ITIH5</i>in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype

Vera Kloten, Michael Rose, Sophie Kaspar, +3

Epigenetics

Unfavorable Overall SurvivalEpigenetic ChangeGeneticsEpigenetic InactivationPathology +19

ITIH5 mediates epigenetic reprogramming of breast cancer cells

Michael Rose, Vera Kloten, Erik Noetzel, +17

Molecular Cancer

Low expression of ITIH5 in adenocarcinoma of the lung is associated with unfavorable patients' outcome

Magnus Mathias Dötsch, Vera Kloten, Martin Schlensog, +6

Epigenetics

Normal Lung TissueImmunologyPathologyCancer BiologyTumor Biology +16

ITIH5 induces a shift in TGF‐β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death

Michael Rose, Steffen K. Meurer, Vera Kloten, +6

Molecular Carcinogenesis

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection

Jolein Mijnes, Janina Tiedemann, Julian Eschenbruch, +19

Oncotarget