TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity

Taras Kreslavsky, Adam K. Savage, Robin M. Hobbs, +6

Proceedings of the National Academy of Sciences

Adaptive Immune SystemGeneticsT-regulatory CellImmune RegulationImmunology +21

Mast cells are an essential hematopoietic component for polyp development

Elias Gounaris, Susan E. Erdman, Clifford R. Restaino, +12

Proceedings of the National Academy of Sciences

Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA.

Giacomo Paonessa, Fotini Gounari, Rainer Frank, +1

The EMBO Journal

Transcriptional RegulationNf1-like Dna-binding ProteinProtein FunctionProtein ExpressionNatural Sciences +8

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling

Kristine Germar, Marei Dose, Tassos Konstantinou, +8

Proceedings of the National Academy of Sciences

Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

Nichole R. Blatner, Mary F. Mulcahy, Kristen L. Dennis, +21

Science Translational Medicine

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential

Colin H. Martin, Iannis Aifantis, M. Lucila Scimone, +4

Nature Immunology

Cell TherapyLymphocyte DevelopmentEfficient Thymic ImmigrationImmunologyAutoimmunity +3

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

Iannis Aifantis, Fotini Gounari, Luca Scorrano, +2

Nature Immunology

InflammationTranscriptional RegulationSignal TransductionSignaling PathwayCell Regulation +10

Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis

Jiangwen Zhang, Audrey Jackson, Taku Naito, +9

Nature Immunology

T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis

Elias Gounaris, Nichole R. Blatner, Kristen L. Dennis, +6

Cancer Research

Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development

Fotini Gounari, Iannis Aifantis, Khashayarsha Khazaie, +4

Nature Immunology

Transcriptional RegulationDevelopmental BiologySignal TransductionSignaling PathwayLymphocyte Development +10