John Chukinas

Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL

Caroline Diorio, Ryan Murray, Mark Naniong et al. · Blood · 2022 · 119 citations · Full text

Cell Therapy, Engineering, In Vivo Gene Therapy +28

Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design

Haiying Qin, Lila Yang, John Chukinas et al. · Journal for ImmunoTherapy of Cancer · 2021 · 67 citations · Full text

CD38 as a pan-hematologic target for chimeric antigen receptor T cells

Tina Glisovic‐Aplenc, Caroline Diorio, John Chukinas et al. · Blood Advances · 2023 · 55 citations · Full text

Hematological Malignancy, Cell Therapy, Autoimmune Disease +15

Potent preclinical activity of FLT3-directed chimeric antigen receptor T-cell immunotherapy against <i>FLT3</i>- mutant acute myeloid leukemia and <i>KMT2A</i>-rearranged acute lymphoblastic leukemia

Lisa M Niswander, Zachary Graff, Christopher D. Chien et al. · Haematologica · 2022 · 47 citations · Full text

Mixed-phenotype Acute Leukemia, T-regulatory Cell, Immunology +16

Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

Bogdan Popescu, Carlos Stahlhut, Theodore C. Tarver et al. · Cell Reports Medicine · 2023 · 11 citations · Full text