Christopher J. Hosford

Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage

Carl J. Schiltz, April Lee, Edward A. Partlow et al. · Nucleic Acids Research · 2019 · 75 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

Yiming Niu, Hiroshi Suzuki, Christopher J. Hosford et al. · Nature Communications · 2020 · 23 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids

Carl J. Schiltz, Jennifer R. Wilson, Christopher J. Hosford et al. · Nature Communications · 2022 · 23 citations · Full text

Life Sciences, Biology, Molecular Biology +17

The structure of the <i>Thermococcus gammatolerans</i> McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs

Christopher J. Hosford, Anthony Bui, Joshua S. Chappie · Journal of Biological Chemistry · 2019 · 20 citations · Full text

Life Sciences, Microbiology, Molecular Biology +15

Structures, activity and mechanism of the Type IIS restriction endonuclease PaqCI

Madison Kennedy, Christopher J. Hosford, Caleigh M. Azumaya et al. · Nucleic Acids Research · 2023 · 19 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17