SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

Ying Wang, Frederick S. Yen, Xiphias Ge Zhu, +13

Nature

Mitochondrial BiogenesisMitochondrial FunctionBiochemistryNatural SciencesMitochondrial Glutathione Import +6

Autoregulatory control of mitochondrial glutathione homeostasis

Yuyang Liu, Shanshan Liu, Anju Tomar, +21

Science

Reductive StressMitochondrial FunctionBiochemistryMedicineMitochondrial Dynamic +11

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

Dorit Hockman, Alan J. Burns, Gerhard Schlosser, +14

eLife

Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism

Erol C. Bayraktar, Konnor La, Kara Karpman, +13

Nature Metabolism

Cholesterol MetabolismOxysterolBiochemistryMetabolic CoessentialityMedicine +11

Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer

Mariluz Soula, Gökhan Ünlü, Rachel L. Welch, +13

Nature

Cancer ImmunosurveillanceImmunologyImmunoeditingGlycosphingolipid Synthesis MediatesImmunotherapy +3

Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies

Gökhan Ünlü, Xinzi Qi, Eric R. Gamazon, +10

Nature Medicine

BiologyGenetic AnalysisMendelian DisorderTranslational BiologyBiobank Associations +11

Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway

Nathan J. Cox, Gökhan Ünlü, Brittany J. Bisnett, +10

Biochemistry

GlycobiologyMolecular BiologyCytoskeletonDynamic Glycosylation GovernsCellular Physiology +19

Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression

Leah Gates, Bernardo Sgarbi Reis, Peder J. Lund, +12

Nature Metabolism

ChromatinChromatin RemodelingEpigenetic ChangeGeneticsGene Expression +7

GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish

Gökhan Ünlü, Eric R. Gamazon, Xinzi Qi, +11

The American Journal of Human Genetics

Ocular DiseaseDevelopmental BiologyVascular PhenomesRetinaGenetics +7

Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability

Gökhan Ünlü, Benjamin Prizer, Ranya Erdal, +3

Molecular Cell

Systems BiologyBiochemistryHeme TransporterIron MetabolismCellular Iron Availability +11