Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments

Jana Ćmielová, Radim Havelek, Tomáš Soukup, +10

International Journal of Radiation Biology

Irradiation of Adult Human Dental Pulp Stem Cells Provokes Activation of p53, Cell Cycle Arrest, and Senescence but Not Apoptosis

Darina Muthná, Tomáš Soukup, Jiřina Vávrová, +9

Stem Cells and Development

Dpscs RespondAdult Stem CellRadiation EffectCell DeathCell Proliferation +20

Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice

Radim Havelek, Darina Muthná, Pavel Tomšík, +8

Chemico-Biological Interactions

Medicinal ChemistryAmaryllidaceae AlkaloidsMedicineHerbal MedicineHerb-drug Interaction +8

DNA Damage Caused by Ionizing Radiation in Embryonic Diploid Fibroblasts WI-38 Induces Both Apoptosis and Senescence

Jana Ćmielová, Radim Havelek, Alena Jiroutová, +5

Physiological Research

ChromatinGenome InstabilityRadiation EffectsDna DamageCell Division +10

[(p-MeC6H4Pr )2Ru2(SC6H4-p-Bu )3]Cl (diruthenium-1), a dinuclear arene ruthenium compound with very high anticancer activity: An in vitro and in vivo study

Pavel Tomšík, Darina Muthná, Martina Řezáčová, +10

Journal of Organometallic Chemistry

Vivo StudyInorganic ChemistryMedicinal ChemistryEngineeringMedicine +8

The Effect of ATM and ERK1/2 Inhibition on Mitoxantrone-Induced Cell Death of Leukaemic Cells

Martina Seifrtová, Radim Havelek, Marcela Chmelařová, +5

Folia Biologica

Erk1/2 InhibitionReductive StressLeukaemic CellsSerine 15Chemoprevention Strategy +13

Boldine and Related Aporphines: From Antioxidant to Antiproliferative Properties

Darina Muthná, Jana Ćmielová, Pavel Tomšík, +1

Natural Product Communications

Bioorganic ChemistryLipid PeroxidationAporphine GroupRedox BiologyOxidative Stress +14

Novel caffeine derivatives with antiproliferative activity

Martin Andrš, Darina Muthná, Martina Řezáčová, +8

RSC Advances

Dna DamageBiochemistryNovel Caffeine DerivativesMedicinePhysiology +12

Caffeine-suppressed ATM pathway leads to decreased p53 phosphorylation and increased programmed cell death in gamma-irradiated leukaemic molt-4 cells

Aleš Tichý, Darina Muthná, Jiřina Vávrová, +4

Journal of Applied Biomedicine

OncologyChemoprevention StrategyMm CaffeineCaffeine-suppressed Atm PathwayCell Cycle Control +13

Boldine Inhibits Mouse Mammary Carcinoma In Vivo and Human MCF-7 Breast Cancer Cells In Vitro

Pavel Tomšík, Stanislav Mičuda, Darina Muthná, +8

Planta Medica