Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy

Carmen Herling, Marion Klaumünzer, Cristiano Krings Rocha, +17

Blood

Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs

Magdalena Laugsch, Michaela Bartusel, Rizwan Rehimi, +14

Cell stem cell

MechanobiologyMusculoskeletal ResearchKinesiologySpinal BiomechanicsGenetic Epidemiology +7

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

Alexandra Schrader, Giuliano Crispatzu, Sebastian Oberbeck, +33

Nature Communications

The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Giuliano Crispatzu, Rizwan Rehimi, Tomás Pachano, +6

Nature Communications

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

Emma Andersson, S. Pützer, Bhagwan Yadav, +36

Leukemia

Novel Drug SensitivitiesPharmaceutical ResearchDrug TargetSignal TransductionEngineering +10

CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia

Oleg Fedorchenko, Marius Stiefelhagen, Abdul Ali Peer‐Zada, +15

Blood

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, +12

Nature Communications

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance

S Spinner, Giuliano Crispatzu, J-H Yi, +20

Leukemia

MitophagyMitochondrial ApoptosisMitochondrial FunctionApoptosisImmunology +8

Mature T-cell Lymphomagenesis Induced by Retroviral Insertional Activation of Janus Kinase 1

Tim Heinrich, Benjamin Rengstl, Alexander Muik, +9

Molecular Therapy

Lymphocyte DevelopmentT-regulatory CellImmunologyPathologyImmunotherapy +15

Noncanonical effector functions of the T-memory–like T-PLL cell are shaped by cooperative TCL1A and TCR signaling

Sebastian Oberbeck, Alexandra Schrader, Kathrin Warner, +42

Blood