Holly C. Cappelli

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

Ravi K. Adapala, Roslin J. Thoppil, Kaustabh Ghosh et al. · Oncogene · 2015 · 151 citations · Full text

Mechanobiology, Cancer Therapy, Signal Transduction +11

TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway

Roslin J. Thoppil, Holly C. Cappelli, Ravi K. Adapala et al. · Oncotarget · 2016 · 89 citations · Full text

TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation

Roslin J. Thoppil, Ravi K. Adapala, Holly C. Cappelli et al. · Scientific Reports · 2015 · 61 citations · Full text

Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis

Holly C. Cappelli, Anantha Koteswararao Kanugula, Ravi K. Adapala et al. · Cancer Letters · 2018 · 52 citations · Full text

Biomedical Engineering, Cellular Physiology, Tumor Biology +16

Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4

Anantha Koteswararao Kanugula, Ravi K. Adapala, Priya Midha et al. · The FASEB Journal · 2018 · 36 citations · Full text