J. Samuel Zigler

Cross-Linking of Lens Crystallins in a Photodynamic System: A Process Mediated by Singlet Oxygen

John D. Goosey, J. Samuel Zigler, Jin H. Kinoshita · Science · 1980 · 205 citations

Medicine, Biochemistry, Ophthalmology +15

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD

Urvi Gupta, Sayan Ghosh, Callen T. Wallace et al. · Autophagy · 2022 · 196 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Oxidative Stress Increases Production of β-Amyloid Precursor Protein and β-Amyloid (Aβ) in Mammalian Lenses, and Aβ Has Toxic Effects on Lens Epithelial Cells

Peter H. Frederikse, Donita Garland, J. Samuel Zigler et al. · Journal of Biological Chemistry · 1996 · 184 citations · Full text

Medicine, Neurobiology, Ophthalmology +15

Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase.

Prashant Rao, C. Murali Krishna, J. Samuel Zigler · Journal of Biological Chemistry · 1992 · 162 citations · Full text

Medicine, Ophthalmology, Enzymology +10

A Super-Family of Medium-Chain Dehydrogenases/Reductases (MDR). Sub-Lines including zeta-Crystallin, Alcohol and Polyol Dehydrogenases, Quinone Oxidoreductases, Enoyl Reductases, VAT-1 and other Proteins

Bengt Persson, J. Samuel Zigler, Hans Jörnvall · European Journal of Biochemistry · 1994 · 154 citations

Life Sciences, Biochemistry, Molecular Biology +6