Activity-based probes for functional interrogation of retaining β-glucuronidases

Liang Wu, Jianbing Jiang, Yi Jin, +12

Nature Chemical Biology

BiochemistryNatural SciencesBioanalysisGlycobiologyAnalytical Chemistry +5

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS

Nan Li, C.J. Kuo, Guillem Paniagua, +10

Nature Protocols

Protein FunctionBiochemistryProtein FoldingMedicineNatural Sciences +8

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

D. Lahav, Bing Liu, Richard J. B. H. N. van den Berg, +15

Journal of the American Chemical Society

Drug TargetGlycobiologySelective InhibitorsChemical BiologyHuman Nonlysosomal Glucosylceramidase +18

Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

Jianbing Jiang, C.J. Kuo, Liang Wu, +10

ACS Central Science

GlycobiologyMolecular BiologyCarbohydrate-protein InteractionChemical BiologyGlycoproteomics +19

<i>In vivo</i> inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling

C.J. Kuo, Wouter W. Kallemeijn, Lindsey T. Lelieveld, +9

FEBS Journal

GlycobiologyNeurochemical BiomarkersCarbohydrate-protein InteractionLysosomal β-Glucosidase-degrading GlucosylceramideGlycoproteomics +15

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

Marta Artola, Liang Wu, María Pía Ferraz, +10

ACS Central Science

A Cleavable Linker Based on the Levulinoyl Ester for Activity‐Based Protein Profiling

Paul P. Geurink, Bogdan I. Florea, Nan Li, +5

Angewandte Chemie International Edition

Protein AssemblyProteasomeMolecular BiologyChemical BiologyStructure-function Enzyme Kinetics +14

Manno-<i>epi</i>-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors

Zachary Armstrong, C.J. Kuo, D. Lahav, +19

Journal of the American Chemical Society

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

Marta Artola, C.J. Kuo, Lindsey T. Lelieveld, +7

Journal of the American Chemical Society

Molecular PharmacologyGaucher DiseaseBiochemistryConduritol B EpoxideMedicine +13

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

Sybrin P. Schröder, Jasper W. van de Sande, Wouter W. Kallemeijn, +13

Chemical Communications