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Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

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PLoS Genetics

Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

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Nature Metabolism

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Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas

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Diabetes

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Nature Metabolism

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Islet-1 Is Essential for Pancreatic β-Cell Function

Benjamin Ediger, Aiping Du, Jingxuan Liu, +7

Diabetes

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Glucagon Deficiency Reduces Hepatic Glucose Production and Improves Glucose Tolerance In Adult Mice

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Molecular Endocrinology

Pancreatic α-Cell Specific Deletion of Mouse Arx Leads to α-Cell Identity Loss

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PLoS ONE

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3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk

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Cell Metabolism

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Arx is required for normal enteroendocrine cell development in mice and humans

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Developmental Biology

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