Heterozygous HIF‐1α deficiency impairs carotid body‐mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

Yingjie Peng, Guoxiang Yuan, DeviPrasadh Ramakrishnan, +5

The Journal of Physiology

Acute Intermittent HypoxiaImmunologyRedox BiologyChronic Intermittent HypoxiaOxidative Stress +16

Induction of HIF‐1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca²⁺ signaling, prolyl hydroxylases, and mTOR

Guoxiang Yuan, Jayasri Nanduri, Shakil A. Khan, +2

Journal of Cellular Physiology

Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia

Guoxiang Yuan, Jayasri Nanduri, C. Raman Bhasker, +2

Journal of Biological Chemistry

Continuous HypoxiaRedox BiologyCellular PhysiologyOxidative StressTranscriptional Regulation +15

Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia

Guoxiang Yuan, Shakil A. Khan, Weibo Luo, +3

Journal of Cellular Physiology

Nadph Oxidase‐2Breathing DisordersRedox BiologyOxidative StressInflammation +16

NADPH Oxidase Is Required for the Sensory Plasticity of the Carotid Body by Chronic Intermittent Hypoxia

Yingjie Peng, Jayasri Nanduri, Guoxiang Yuan, +6

Journal of Neuroscience

Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities

Jayasri Nanduri, Ning Wang, Guoxiang Yuan, +6

Proceedings of the National Academy of Sciences

Redox SignalingTranscriptional RegulationSignal TransductionIntermittent HypoxiaCalpain Proteases +12

Role of oxidative stress in intermittent hypoxia‐induced immediate early gene activation in rat PC12 cells

Guoxiang Yuan, Gautam Adhikary, Andrew McCormick, +3

The Journal of Physiology

Continuous HypoxiaRedox BiologyCellular PhysiologyOxidative StressTranscriptional Regulation +14

Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis

Jayasri Nanduri, Vladislav Makarenko, Vaddi Damodara Reddy, +12

Proceedings of the National Academy of Sciences

Developmental BiologyIntermittent HypoxiaMedicinePhysiologyDna Methylation +10

Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

Yingjie Peng, Jayasri Nanduri, Shakil A. Khan, +8

Proceedings of the National Academy of Sciences

Protein kinase G–regulated production of H ₂ S governs oxygen sensing

Guoxiang Yuan, Chirag Vasavda, Yingjie Peng, +8

Science Signaling