Kyoko Takeda

Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.

Atsushi Sakurai, Kyoko Takeda, Kenneth B. Ain et al. · Proceedings of the National Academy of Sciences · 1989 · 266 citations · Full text

Signal Transduction, Ligand-binding Domain, Endocrine Mechanism +14

Recessive inheritance of thyroid hormone resistance caused by complete deletion of the protein-coding region of the thyroid hormone receptor-beta gene.

Kyoko Takeda, A Sakurai, Leslie J. DeGroot et al. · The Journal of Clinical Endocrinology & Metabolism · 1992 · 194 citations

Htr Beta Gene, Systems Biology, Developmental Biology +15

Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation.

Kyoko Takeda, S. Balzano, Akihiro Sakurai et al. · Journal of Clinical Investigation · 1991 · 85 citations · Full text

Genetics, Genetic Epidemiology, Pathology +17

Rapid localization of mutations in the thyroid hormone receptor-beta gene by denaturing gradient gel electrophoresis in 18 families with thyroid hormone resistance

Kyoko Takeda, Roy E. Weiss, Samuel Refetoff · The Journal of Clinical Endocrinology & Metabolism · 1992 · 70 citations

Htr Beta Gene, Point Mutations, Genetic Disorder +13

Sequence of the variant thyroxine-binding globulin of Australian aborigines. Only one of two amino acid replacements is responsible for its altered properties.

Kyoko Takeda, Y Mori, S Sobieszczyk et al. · Journal of Clinical Investigation · 1989 · 68 citations · Full text

Biochemistry, Tbg Gene, Genetics +13