Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.

Atsushi Sakurai, Kyoko Takeda, Kenneth B. Ain, +6

Proceedings of the National Academy of Sciences

Signal TransductionLigand-binding DomainEndocrine MechanismMedicineGenetics +12

Recessive inheritance of thyroid hormone resistance caused by complete deletion of the protein-coding region of the thyroid hormone receptor-beta gene.

Kyoko Takeda, A Sakurai, Leslie J. DeGroot, +1

The Journal of Clinical Endocrinology & Metabolism

Htr Beta GeneSystems BiologyDevelopmental BiologyRecessive InheritanceGenetic Disorder +13

Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation.

Kyoko Takeda, S. Balzano, Akihiro Sakurai, +2

Journal of Clinical Investigation

GeneticsGenetic EpidemiologyPathologyMolecular BiologyMolecular Genetics +15

Rapid localization of mutations in the thyroid hormone receptor-beta gene by denaturing gradient gel electrophoresis in 18 families with thyroid hormone resistance

Kyoko Takeda, Roy E. Weiss, Samuel Refetoff

The Journal of Clinical Endocrinology & Metabolism

Htr Beta GenePoint MutationsGenetic DisorderRapid LocalizationGenetics +11

Sequence of the variant thyroxine-binding globulin of Australian aborigines. Only one of two amino acid replacements is responsible for its altered properties.

Kyoko Takeda, Y Mori, S Sobieszczyk, +7

Journal of Clinical Investigation

BiochemistryTbg GeneGeneticsPathogenesisNatural Sciences +11

Regulatory Role of the GTP‐Binding Protein, G_o, in the Mechanism of Exocytosis in Adrenal Chromaffin Cells

Mica Ohara‐Imaizumi, Kimihiko Kameyama, Nobuyuki Kawae, +2

Journal of Neurochemistry

Structural Analysis of Unsaturated Hexasaccharides Isolated from Shark Cartilage Chondroitin Sulfate D that are Substrates for the Exolytic Action of Chondroitin ABC Lyase

Kazuyuki Sugahara, Satomi Nadanaka, Kyoko Takeda, +1

European Journal of Biochemistry

Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.

Yoshitaka Hayashi, Y Mori, T Sunthornthepvarakul, +6

Molecular Endocrinology

Transcriptional RegulationProtein ExpressionExon 1Exon 0Genetics +10

Increased Insulin Sensitivity in Gsα Knockout Mice

Shuhua Yu, Arthur L. Castle, Min Chen, +3

Journal of Biological Chemistry

Replacement of Leu²²⁷by Pro in Thyroxine-Binding Globulin (TBG) Is Associated with Complete TBG Deficiency in Three of Eight Families with This Inherited Defect*

Yuichi Mori, Kyoko Takeda, MYRIAM CHARBONNEAU, +1

The Journal of Clinical Endocrinology & Metabolism