Peter Rüngeler

Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action

Peter Rüngeler, Vı́ctor Castro, Gerardo Mora et al. · Bioorganic & Medicinal Chemistry · 1999 · 245 citations

Inflammation, Molecular Pharmacology, Transcriptional Regulation +9

Quantitative Structure−Activity Relationship of Sesquiterpene Lactones as Inhibitors of the Transcription Factor NF-κB

Bettina Siedle, Alfonso Garcı́a-Piñeres, Renato Murillo et al. · Journal of Medicinal Chemistry · 2004 · 242 citations

Study of Three Sesquiterpene Lactones from<i>Tithonia diversifolia</i>on their Anti-Inflammatory Activity Using the Transcription Factor NF-κB and Enzymes of the Arachidonic Acid Pathway as Targets

Peter Rüngeler, Guido Lyß, Vı́ctor Castro et al. · Planta Medica · 1998 · 76 citations

Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-κB 1 1Abbreviations: Con A, concanavalin A; HBSS, Hanks’ balanced salt solution; IL, interleukin; iNOS, inducible nitric oxide synthase; LPS, lipopolysaccharide; NF-κB, nuclear factor kappaB; NO, nitric oxide; PEC, mouse peritoneal exsudate cell; TNF-α, tumor necrosis factor α; and Sl(s), sesquiterpene lactone(s).

E Koch, Christoph A. Klaas, Peter Rüngeler et al. · Biochemical Pharmacology · 2001 · 58 citations

Inflammation, Cytokine, Anti-inflammatory +14

Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-κB as molecular target

Vı́ctor Castro, Peter Rüngeler, Ramón Murillo et al. · Phytochemistry · 2000 · 43 citations

Inflammation, Anti-inflammatory, Biochemistry +7