Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications

Barbara A. Wood, Kevin P. Girard, Christopher S. Polster, +1

Organic Process Research & Development

Materials ScienceProcess IntensificationEngineeringPharmaceutical ApplicationsCrystal Material +13

Perspectives on the Current State, Challenges, and Opportunities in Pharmaceutical Crystallization Process Development

Aaron Cote, Deniz Erdemir, Kevin P. Girard, +4

Crystal Growth & Design

Materials ScienceSynthetic Pharmaceutical CompoundsCrystallization DesignSurface AreaEngineering +13

The effect of agitated drying on the morphology of l-threonine (needle-like) crystals

Azzeddine Lekhal, Kevin P. Girard, Matthew Brown, +3

International Journal of Pharmaceutics

Materials ScienceThixotropyEngineeringChemistryCrystal Formation +2

Impact of agitated drying on crystal morphology: KCl–water system

Azzeddine Lekhal, Kevin P. Girard, Matthew Brown, +3

Powder Technology

Materials ScienceEngineeringDesiccationWettingKcl–water System +2

Control of the Particle Properties of a Drug Substance by Crystallization Engineering and the Effect on Drug Product Formulation

Soojin Kim, Bruce Lotz, Mark Lindrud, +9

Organic Process Research & Development

Pharmaceutical ScienceEngineeringApi CrystalsCrystal AttritionCrystallization Engineering +16

3D printing of PEEK reactors for flow chemistry and continuous chemical processing

M. J. Harding, Sarah R. Brady, Heather O'Connor, +7

Reaction Chemistry & Engineering

EngineeringMechanical EngineeringBiofabricationPeek ReactorsAdvanced Manufacturing +15

Computational fluid dynamics modeling of mixing effects for crystallization in coaxial nozzles

C. Pirkle, Lucas C. Foguth, Steven J. Brenek, +2

Chemical Engineering and Processing - Process Intensification

EngineeringFluid MechanicsMechanical EngineeringNumerical SimulationApplied Physics +8

Process analytical technology (PAT): applications to flow processes for active pharmaceutical ingredient (API) development

Courtney Talicska, Eamon C. O'Connell, Howard W. Ward, +6

Reaction Chemistry & Engineering

Active Pharmaceutical IngredientEngineeringProcess DevelopmentPharmaceutical FormulationChemical Engineering +15

Cross-Pharma Collaboration for the Development of a Simulation Tool for the Model-Based Digital Design of Pharmaceutical Crystallization Processes (CrySiV)

Botond Szilágyi, Wei-Lee Wu, Ayşe Eren, +38

Crystal Growth & Design

EngineeringChemical AnalysisModel-based Digital DesignCross-pharma CollaborationProcess Development +21

Automated and Material-Sparing Workflow for the Measurement of Crystal Nucleation and Growth Kinetics

Ryan J. Arruda, Paul A.J. Cally, Anthony Wylie, +12

Crystal Growth & Design

Crystal NucleationEngineeringChemical AnalysisCrystal Growth TechnologyChemistry +19