Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis

Melissa Schepers, Dean Paes, Assia Tiane, +24

Brain Behavior and Immunity

Neurological DisorderImmunologyImmunotherapySocial SciencesNeuroinflammation +16

Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer’s disease

Dean Paes, Roy Lardenoije, Riccardo M. Carollo, +10

Neurobiology of Aging

Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition

Nick P. van Goethem, Dean Paes, Daniela Puzzo, +8

Cellular Signalling

Mla AdministrationNeuropsychologySynaptic TransmissionNeurotransmitterPsychopharmacology +25

Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology

Dean Paes, Melissa Schepers, Emily Willems, +14

Cellular and Molecular Life Sciences

Investigations into the genotoxic potential of loxtidine, a long-acting H2-receptor antagonist

D. Gatehouse, D.J. Wedd, Dean Paes, +6

Mutagenesis

ImmunologyPharmacotherapyToxicological MechanismDrug ResistanceToxicology +15

Inhibition of PDE2 and PDE4 synergistically improves memory consolidation processes

Dean Paes, Keqiang Xie, Damian G. Wheeler, +3

Neuropharmacology

Storage (Memory)Cognitive ScienceAlzheimer's DiseaseMemory SystemMnemonic +8

Computational investigation of the dynamic control of cAMP signaling by PDE4 isoform types

Dean Paes, Sammy Hermans, Daniël van den Hove, +3

Biophysical Journal

Biophysical ModelingSignal TransductionMolecular PhysiologyCamp SignalingMedicine +9

Early‐postnatal iron deficiency impacts plasticity in the dorsal and ventral hippocampus in piglets

Ellis Nelissen, Jochen De Vry, Alexandra Antonides, +5

International Journal of Developmental Neuroscience

Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory

Susan C. McQuown, Dean Paes, Karsten Baumgärtel, +2

Neurobiology of Learning and Memory

Biased 5-HT1A receptor agonists F13714 and NLX-101 differentially affect pattern separation and neuronal plasticity in rats after acute and chronic treatment

Britt T.J. van Hagen, Nick P. van Goethem, Ellis Nelissen, +7

Molecular and Cellular Neuroscience