Rev-Independent Expression of Synthetic <i>gag-pol</i> Genes of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus: Implications for the Safety of Lentiviral Vectors

Ralf Wagner, Marcus Graf, Kurt Bieler, +4

Human Gene Therapy

Proline Residues in the HIV-1 NH2-Terminal Capsid Domain: Structure Determinants for Proper Core Assembly and Subsequent Steps of Early Replication

T. Fitzon, Bernd Leschonsky, Kurt Bieler, +4

Virology

Virus StructureViral ReplicationBiochemistryNatural SciencesHuman Retrovirus +8

Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade C

Carmen Gómez, José Luis Nájera, Victoria Jiménez, +11

Vaccine

VaccinationVaccine TargetClade CHuman RetrovirusImmunology +8

Concerted Action of Multiple <i>cis</i> -Acting Sequences Is Required for Rev Dependence of Late Human Immunodeficiency Virus Type 1 Gene Expression

Marcus Graf, Alexandra Bojak, Ludwig Deml, +3

Journal of Virology

Qualitative T-Helper Responses to Multiple Viral Antigens Correlate with Vaccine-Induced Immunity to Simian/Human Immunodeficiency Virus Infection

Petra Mooij, Ivonne G. Nieuwenhuis, Christiaan J. Knoop, +12

Journal of Virology

Comparison of Human and Rhesus Macaque T-Cell Responses Elicited by Boosting with NYVAC Encoding Human Immunodeficiency Virus Type 1 Clade C Immunogens

Petra Mooij, Sunita S. Balla-Jhagjhoorsingh, Niels Beenhakker, +14

Journal of Virology

ImmunologyCd4 T Cell ResponsesImmunotherapyViral PersistenceRhesus Monkeys +14

Capsid stability and replication of human immunodeficiency virus type 1 are influenced critically by charge and size of Gag residue 183

Bernd Leschonsky, Christine Ludwig, Kurt Bieler, +1

Journal of General Virology

Preclinical Evaluation of the Immunogenicity of C-Type HIV-1-Based DNA and NYVAC Vaccines in the Balb/C Mouse Model

Jens Wild, Kurt Bieler, Josef Köstler, +8

Viral Immunology

Nyvac VaccinesImmunologyImmunotherapyBalb/c Mouse ModelVaccine Target +17

HIV-1 gag expression is quantitatively dependent on the ratio of native and optimized codons.

Alexander Kofman, Marcus Graf, Alexandra Bojak, +5

PubMed

Viral ReplicationEngineeringImmunologyMolecular BiologyOptimized Codons +15

Better Protective Effects in Rhesus Macaques by Combining Systemic and Mucosal Application of a Dual Component Vector Vaccine After Rectal SHIV89.6P Challenge Compared to Systemic Vaccination Alone

Nicole Stolte‐Leeb, Kurt Bieler, Josef Köstler, +6

Viral Immunology

ImmunologyImmunotherapySystemic VaccinationCross-protectionRhesus Macaques +15