NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Doris Höglinger, Thomas Burgoyne, Elena Sánchez-Heras, +7

Nature Communications

Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

Clément Oyeniran, Jamie Sturgill, Nitai C. Hait, +9

Journal of Allergy and Clinical Immunology

AsthmaInflammationInflammatory Lung DiseaseAllergyLung Inflammation +10

Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma

Briana N. James, Clément Oyeniran, Jamie Sturgill, +12

Journal of Allergy and Clinical Immunology

AsthmaInflammationAnti-inflammatoryAllergyMedicine +8

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann‐Pick type C mutant fibroblasts

Jason Newton, Nitai C. Hait, Michael Maceyka, +9

The FASEB Journal

Early hemostatic responses to trauma identified with hierarchical clustering analysis

Nathan J. White, Daniel Contaifer, Erika J. Martin, +8

Journal of Thrombosis and Haemostasis

Trauma ResuscitationHealth SciencesTraumatologyHematologyHierarchical Clustering Analysis +9

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

Santiago Lima, Kazuaki Takabe, Jason Newton, +10

Autophagy

ApoptosisImmunologyCell DeathTumor BiologyCell Autophagy +16

Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer

Melissa A. Maczis, Michael Maceyka, Michael R. Waters, +8

Journal of Lipid Research

Breast OncologyCancer BiologyMammary Gland DevelopmentTumor BiologyEndocrine Oncology +14

CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism

Christopher D. Green, Cynthia Weigel, Clément Oyeniran, +7

Journal of Lipid Research

Platelets retain inducible alpha granule secretion by P‐selectin expression but exhibit mechanical dysfunction during trauma‐induced coagulopathy

Alexander E. St. John, Jason Newton, Erik.J. Martin, +9

Journal of Thrombosis and Haemostasis

Platelet BiologyMechanobiologyThrombosisEngineeringBlood Platelet +11

Clot Formation Is Associated With Fibrinogen and Platelet Forces in a Cohort of Severely Injured Emergency Department Trauma Patients

Nathan J. White, Jason Newton, Erika J. Martin, +8

Shock