Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade

Fei Zhang, Hudie Wei, Xiaoxiao Wang, +8

Cell Discovery

Structural basis of a novel heterodimeric Fc for bispecific antibody production

Hudie Wei, Haiyan Cai, Yuhao Jin, +8

Oncotarget

Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab

Fei Zhang, Xiaoqiang Qi, Xiaoxiao Wang, +9

Oncotarget

Targeting USP9x/SOX2 axis contributes to the anti-osteosarcoma effect of neogambogic acid

Xiangyun Chen, Xingming Zhang, Haiyan Cai, +9

Cancer Letters

SclerostinNeogambogic AcidMedicineAnti-osteosarcoma EffectPathology +6

CDDO-Me reveals USP7 as a novel target in ovarian cancer cells

Dongjun Qin, Weiwei Wang, Hu Lei, +13

Oncotarget

The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

Meng-Kai Ge, Cheng Zhang, Na Zhang, +15

Cell Metabolism

Amino Acid InsufficiencyProtein FunctionSignal TransductionBiochemistryNatural Sciences +3

Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro

Bo Jing, Meng Liu, Li Yang, +12

Acta Pharmacologica Sinica

Medicinal ChemistryPharmaceutical ScienceBiochemistryProtease Usp7Medicine +7

Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice

Haiyan Cai, Ting Wang, Jian-chun Zhao, +7

Acta Pharmacologica Sinica

Metabolic SyndromeBiochemistryHuman Fatty AcidOld Uricosuric DrugPhysiology +7

Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination

Haiyan Cai, Qiufeng Liu, Dingding Gao, +8

European Journal of Medicinal Chemistry

Molecular DockingVirtual ScreeningLipid SynthesisBiochemistryBiomolecular Structure Prediction +9

Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening

Haiyan Cai, Guirui Yan, Xiaodong Zhang, +3

Bioorganic & Medicinal Chemistry Letters

Molecular DockingVirtual ScreeningDrug TargetLipid SynthesisBiochemistry +8