H. T. Henry Chan

Discovery of SARS-CoV-2 M ^pro peptide inhibitors from modelling substrate and ligand binding

H. T. Henry Chan, Marc A. Moesser, Rebecca K. Walters et al. · Chemical Science · 2021 · 89 citations · Full text

Life Sciences, Medicinal Chemistry, Structural Biology +2

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M^pro inhibitors

Tika R. Malla, Anthony Tumber, Tobias John et al. · Chemical Communications · 2021 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Fluorophore-Labeled β-Lactamase as a Biosensor for β-Lactam Antibiotics: A Study of the Biosensing Process

Pak‐Ho Chan, Pui‐Kin So, Dik‐Lung Ma et al. · Journal of the American Chemical Society · 2008 · 38 citations

Engineering, Biochemistry, Molecular Biology +17

Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease

H. T. Henry Chan, A. Sofia F. Oliveira, Christopher J. Schofield et al. · JACS Au · 2023 · 37 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by <scp>l,d</scp>‐Transpeptidases and Serine β‐Lactamase Cysteine Variants

Christopher T. Lohans, H. T. Henry Chan, Tika R. Malla et al. · Angewandte Chemie International Edition · 2018 · 36 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +15