Trevor Chapman

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittmann et al. · Nature · 2011 · 1.5K citations · Full text

Life Sciences, Hematology, Molecular Biology +10

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762

Aristeidis Chaidos, Valentina S. Caputo, Katerina Gouvedenou et al. · Blood · 2013 · 202 citations

Pharmacy, Medicinal Chemistry, Pharmacology +6

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach

Zuni I. Bassi, Martin C. Fillmore, Afjal H. Miah et al. · ACS Chemical Biology · 2018 · 178 citations

Life Sciences, Immunology, Molecular Biology +17

A global benchmark study using affinity-based biosensors

Rebecca L. Rich, Giuseppe A. Papalia, Peter J. Flynn et al. · Analytical Biochemistry · 2008 · 97 citations · Full text

Engineering, Bioengineering, Biomedical Engineering +9

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

Hideyuki Yoshida, Kushagra Bansal, Uwe Schaefer et al. · Proceedings of the National Academy of Sciences · 2015 · 63 citations · Full text

Life Sciences, Immunology, Molecular Biology +17