DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

Silvia Monteagudo, F.M. Cornelis, Carolina Aznar-Lopez, +5

Nature Communications

Efficient, Non-Toxic Hybrid PPV-PAMAM Dendrimer as a Gene Carrier for Neuronal Cells

Ana C. Rodrigo, Iván Rivilla, Francisco C. Pérez‐Martínez, +7

Biomacromolecules

Novel Hybrid DendrimerEngineeringGene CarrierGene DeliveryBiomedical Engineering +17

Inhibition of P42 MAPK Using A Nonviral Vector-Delivered siRNA Potentiates The Anti-Tumor Effect of Metformin in Prostate Cancer Cells

Silvia Monteagudo, Francisco C. Pérez‐Martínez, María Dolores Pérez‐Carrión, +3

Nanomedicine

Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice

F.M. Cornelis, Astrid De Roover, L. Storms, +3

Osteoarthritis and Cartilage

InflammationRheumatologyPost-traumatic OsteoarthritisInflammatory DiseaseMusculoskeletal Research +8

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone

F.M. Cornelis, Silvia Monteagudo, Laura-An Guns, +7

Science Translational Medicine

Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis

Reem Assi, C. Cherifi, F.M. Cornelis, +7

Annals of the Rheumatic Diseases

Exostosin-1 enhances canonical Wnt signaling activity during chondrogenic differentiation

X. Wang, F.M. Cornelis, Rik Lories, +1

Osteoarthritis and Cartilage

Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis

Astrid De Roover, Ana Escribano-Núñez, F.M. Cornelis, +6

JCI Insight

ImmunologyOrthopaedic SurgeryMusculoskeletal ResearchInflammationRheumatoid Disorder +18

Role of Generation, Architecture, pH and Ionic Strength on Successful siRNA Delivery and Transfection by Hybrid PPV-PAMAM Dendrimers

Giovanni M. Pavan, Silvia Monteagudo, Javier Guerra, +6

Current Medicinal Chemistry

Complement component C1q is produced by isolated articular chondrocytes

Rosalie Lubbers, Rosanne A. van Schaarenburg, Joanneke C. Kwekkeboom, +9

Osteoarthritis and Cartilage

InflammationComplement SystemMusculoskeletal ResearchImmunologyOsteoarthritis +5