Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway

Tatsushi Igaki

The EMBO Journal

Drosophila Jnk PathwaySignal TransductionSignaling PathwayGeneticsGene Regulation +4

Loss of Cell Polarity Drives Tumor Growth and Invasion through JNK Activation in Drosophila

Tatsushi Igaki, Raymond Pagliarini, Tian Xu

Current Biology

Signal TransductionDevelopmental BiologySignaling PathwayCell RegulationMedicine +8

Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

Tatsushi Igaki, Hiroka Aonuma, Masayuki Miura, +1

Developmental Cell

Developmental BiologySignal TransductionCell RegulationSignaling PathwayIntrinsic Tumor Suppression +9

Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila

Shizue Ohsawa, Kaoru Sugimura, Kyoko Takino, +3

Developmental Cell

Cell DivisionNatural SciencesGene RegulationJnk-mediated EngulfmentMolecular Genetics +4

Wengen, a Member of the Drosophila Tumor Necrosis Factor Receptor Superfamily, Is Required for Eiger Signaling

Hiroshi Kanda, Tatsushi Igaki, Hirotaka Kanuka, +2

Journal of Biological Chemistry

Systems BiologySignal TransductionDrosophila TnfTnfr Homology DomainSignaling Pathway +9

Basement membrane remodeling is essential for <i>Drosophila</i> disc eversion and tumor invasion

Ajay Srivastava, Tatsushi Igaki, Raymond Pagliarini, +1

Proceedings of the National Academy of Sciences

Cell ProliferationCellular PhysiologyTumor BiologyTumor InvasionMmp Inhibitors +16

Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila

Shizue Ohsawa, Yoshitaka Sato, Masato Enomoto, +3

Nature

Genome InstabilityMitophagyDevelopmental BiologyMitochondrial DefectMitochondrial Function +6

Drob-1, a <i>Drosophila</i> member of the Bcl-2/CED-9 family that promotes cell death

Tatsushi Igaki, Hirotaka Kanuka, Naohiro Inohara, +4

Proceedings of the National Academy of Sciences

GeneticsApoptosisCell DeathBcl-2/ced-9 FamilyMolecular Genetics +17

The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition

Masatoshi Yamamoto, Shizue Ohsawa, Kei Kunimasa, +1

Nature

Cancer ResearchMedicineLigand SasImmune Checkpoint InhibitorTumor Suppressor +5

Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila

Erina Kuranaga, Hirotaka Kanuka, Tatsushi Igaki, +4

Nature Cell Biology

Signal TransductionSignaling PathwayCell RegulationNatural SciencesGene Expression +9