Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer

Anthony W. Goering, Ryan A. McClure, James R. Doroghazi, +7

ACS Central Science

Bioorganic ChemistryMetabolomic ProfilingSecondary MetaboliteMetabolic ModelDrug Resistance +21

<i>In Vitro</i> Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis

Anthony W. Goering, Jian Li, Ryan A. McClure, +3

ACS Synthetic Biology

Large-Scale Metabolomics Reveals a Complex Response of <i>Aspergillus nidulans</i> to Epigenetic Perturbation

Jessica C. Albright, Matthew T. Henke, Alexandra A. Soukup, +4

ACS Chemical Biology

EngineeringMetabolomic ProfilingMedicinal FungiSecondary MetaboliteHistone Deacetylase Activity +19

Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations

Ryan A. McClure, Anthony W. Goering, Kou‐San Ju, +5

ACS Chemical Biology

Nrps/pks-type Gene ClusterMedicinal ChemistryBiosynthesisBioorganic ChemistryNew Family +13

New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in <i>Aspergillus nidulans</i>

Matthew T. Henke, Alexandra A. Soukup, Anthony W. Goering, +4

ACS Chemical Biology

Fungal Cell BiologyFuture PharmaceuticalsMolecular BiologyNew AspercryptinsMedicinal Fungi +15

Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster <i>via</i> Metabologenomics

Elizabeth I. Parkinson, James H. Tryon, Anthony W. Goering, +8

ACS Chemical Biology

Bioorganic ChemistryEngineeringMetabolomic ProfilingSecondary MetaboliteMedicinal Chemistry +15

The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy

Sven Malchow, Alla Korepanova, Sanjay C. Panchal, +20

ACS Chemical Biology

Gobichelin A and B: mixed-ligandsiderophores discovered using proteomics

Yunqiu Chen, Michelle Unger, Ioanna Ntai, +4

MedChemComm

Bioorganic ChemistryEngineeringBiomolecular Structure PredictionNatural Product DiscoveryProteomic Technology +15

Proteomics Guided Discovery of Flavopeptins: Anti-proliferative Aldehydes Synthesized by a Reductase Domain-Containing Non-ribosomal Peptide Synthetase

Yunqiu Chen, Ryan A. McClure, Yupeng Zheng, +2

Journal of the American Chemical Society

Bioorganic ChemistryAldo-keto ReductasePeptide EngineeringGlycobiologyMolecular Biology +15

Impact of Mass Spectrometry-Based Technologies and Strategies on Chemoproteomics as a Tool for Drug Discovery

Ryan A. McClure, Jon D. Williams

ACS Medicinal Chemistry Letters