Guangya Zhu

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Guangya Zhu, Jingjing Xie, Wenna Kong et al. · Cell · 2020 · 260 citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +5

Targeting androgen receptor phase separation to overcome antiandrogen resistance

Jingjing Xie, Hao He, Wenna Kong et al. · Nature Chemical Biology · 2022 · 143 citations

Antiandrogen Resistance, Medicine, Hormonal Receptor +4

An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation

Jingjing Xie, Guangya Zhu, Ming Gao et al. · CCS Chemistry · 2021 · 15 citations · Full text

Phase separation underlies signaling activation of oncogenic NTRK fusions

Tianxin Zhu, Jingjing Xie, Hao He et al. · Proceedings of the National Academy of Sciences · 2023 · 15 citations · Full text

Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration

Hengyi Cao, Guangya Zhu, Lin Sun et al. · European Journal of Medicinal Chemistry · 2019 · 14 citations · Full text

Isocitrate Dehydrogenase 1, Drug Targeting, Drug Target +10