Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

Wufan Tao, Sheng Zhang, Gregory S. Turenchalk, +4

Nature Genetics

Drosophila MelanogasterSignal TransductionSignaling PathwayCell RegulationTumor Suppressor +6

Malignant Transformation Initiated by Mll-AF9: Gene Dosage and Critical Target Cells

Weili Chen, Ashish Kumar, Wendy A. Hudson, +6

Cancer Cell

Critical Target CellsGene DosageOncogenic AgentMedicineMalignant Transformation +7

Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium

Beth A. Lindborg, John H. Brekke, Amanda L. Vegoe, +15

Stem Cells Translational Medicine

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia

Ashish Kumar, Wendy A. Hudson, Weili Chen, +3

Blood

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy

Weili Chen, Quanzhi Li, Wendy A. Hudson, +3

Blood

Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis

Xiaolong Yang, Daming Li, Weili Chen, +1

Oncogene

Developmental BiologyCell RegulationCell DivisionGeneticsDrosophila Lats +8

ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

Maxime W.C. Rousseaux, Tyler Tschumperlin, Hsiang‐Chih Lu, +18

Neuron

Synaptic SignalingMedicineAtxn1-cic ComplexNeuroscienceCentral Nervous System +4

Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling

Ke Jiang, Qing Lü, Qiong Li, +3

International Immunopharmacology

Breast OncologyChemoprevention StrategyMedicineReceptor Tyrosine KinaseBreast Cancer +7

Rapid DNA replication origin licensing protects stem cell pluripotency

Jacob P. Matson, ‎Raluca Dumitru, Philip Coryell, +8

eLife

GeneticsCell PluripotencyOrigin LicensingCell CycleEpigenetics +14

A role for MEIS1 in MLL-fusion gene leukemia

Ashish Kumar, Quanzhi Li, Wendy A. Hudson, +7

Blood