Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells

Mamiko Kobayashi, Daisuke Mikami, Hideki Kimura, +7

Biochemical and Biophysical Research Communications

Renal InflammationGpr43 LigandsTnf-α-induced Mcp-1 ExpressionInflammationSignaling Pathway +15

A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells

Mamiko Kobayashi, Daisuke Mikami, Junsuke Uwada, +5

Oncotarget

Biodisposition Characteristics of N-Succinyl-chitosan and Glycol-chitosan in Normal and Tumor-bearing Mice.

Kazuko Kamiyama, Hiraku Onishi, Yoshiharu Machida

Biological and Pharmaceutical Bulletin

EngineeringGlycobiologyPolysaccharideTumor BiologyBiodisposition Characteristics +17

AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis <i>via</i> HDAC inhibition

Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, +8

Therapeutic Advances in Medical Oncology

β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cells

Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, +8

Journal of Pharmacological Sciences

Chemoprevention StrategyApoptosisCell DeathCancer BiologyTumor Biology +21

Telmisartan activates endogenous peroxisome proliferator-activated receptor-δ and may have anti-fibrotic effects in human mesangial cells

Daisuke Mikami, Hideki Kimura, Kazuko Kamiyama, +5

Hypertension Research

InflammationMolecular PharmacologyFibrosisMolecular PhysiologySignal Transduction +11

Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways

Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, +10

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Metabolic SyndromeUrologyBiochemistryOmega-3 Fatty AcidMedicine +9

β-Hydroxybutyrate, a ketone body, reduces the cytotoxic effect of cisplatin via activation of HDAC5 in human renal cortical epithelial cells

Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, +10

Life Sciences

Molecular PharmacologyKetone BodyUrologyChemoprevention StrategyMedicine +4

Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis

Yukie Morikawa, Naoki Takahashi, Kazuko Kamiyama, +13

˜The œNephron journals/Nephron journals

Chronic hypoxia exacerbates diabetic glomerulosclerosis through mesangiolysis and podocyte injury in db/db mice

Naoki Takahashi, Haruyoshi Yoshida, Hideki Kimura, +12

Nephrology Dialysis Transplantation