Lesley S. Sheehan

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Aleksandra Wlodek, Steve Kendrew, Nigel J. Coates et al. · Nature Communications · 2017 · 91 citations · Full text

Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors

Ming‐Qiang Zhang, Sabine Gaisser, Mohammad Nur‐e‐Alam et al. · Journal of Medicinal Chemistry · 2008 · 86 citations

Biosynthetic Engineering, Pharmaceutical Science, Bioorganic Chemistry +20

Engineering of the Spinosyn PKS:  Directing Starter Unit Incorporation

Lesley S. Sheehan, Rachel E. Lill, Barrie Wilkinson et al. · Journal of Natural Products · 2006 · 50 citations

Engineering, Spin Systems, Chemical Modification +17

Rapamycin biosynthesis: elucidation of gene product function

Matthew A. Gregory, Hui Hong, Rachel E. Lill et al. · Organic & Biomolecular Chemistry · 2006 · 48 citations

Conditional language models enable the efficient design of proficient enzymes

Geraldene Munsamy, R. Illanes, Silvia Fruncillo et al. · 2024 · 36 citations · Full text

Functional Enzymes, Engineering, Molecular Biology +27