Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

Kiyohiro Takahasi, Mitsutoshi Yoneyama, Tatsuya Nishihori, +6

Molecular Cell

Viral ReplicationNonself Rna-sensing MechanismImmunologyAntiviral ResponseMolecular Biology +6

Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains

Kiyohiro Takahasi, Hiroyuki Kumeta, N. Tsuduki, +8

Journal of Biological Chemistry

DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation

Ji‐Seung Yoo, Kiyohiro Takahasi, Chen Seng Ng, +10

PLoS Pathogens

InflammationRna Virus InfectionViral ReplicationCytokineSignal Transduction +13

X-ray crystal structure of IRF-3 and its functional implications

Kiyohiro Takahasi, Nobuo Suzuki, Masataka Horiuchi, +8

Nature Structural & Molecular Biology

Materials ScienceX-ray CrystallographyCrystal StructureEngineeringX-ray Crystal Structure +3

Structural Basis for the Antiproliferative Activity of the Tob-hCaf1 Complex

Masataka Horiuchi, Kosei Takeuchi, Nobuo N. Noda, +7

Journal of Biological Chemistry

Solution structure of the silkworm βGRP/GNBP3 N-terminal domain reveals the mechanism for β-1,3-glucan-specific recognition

Kiyohiro Takahasi, Masanori Ochiai, Masataka Horiuchi, +4

Proceedings of the National Academy of Sciences

GlycobiologyMolecular BiologyInnate ImmunitySolution StructureBeta-1,3-glucan Recognition Protein +14

A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection

Ryo Narita, Kiyohiro Takahasi, Etsu Murakami, +5

PLoS Pathogens

Viral PathogenesisImmunologyViral InfectionInnate ImmunityViral Structural Protein +18

Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Down-regulation of the Very Low Density Lipoprotein Receptor

Ryota Ouda, Koji Onomoto, Kiyohiro Takahasi, +4

Journal of Biological Chemistry

Innate Immune ReceptorsInnate Immune SystemViral PathogenesisImmunologyPathology +17

Ser386 phosphorylation of transcription factor IRF‐3 induces dimerization and association with CBP/p300 without overall conformational change

Kiyohiro Takahasi, Masataka Horiuchi, Kiyonaga Fujii, +5

Genes to Cells

Crystal StructureMolecular RegulationMolecular BiologyTranscriptional RegulationSignaling Pathway +18

Functional Characterization of Domains of IPS-1 Using an Inducible Oligomerization System

Shiori Takamatsu, Kazuhide Onoguchi, Koji Onomoto, +7

PLoS ONE

Innate Immune SystemImmunologyMolecular BiologyInnate ImmunityInducible Oligomerization System +18