David B. A. James

Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin

Tyler D. Scherr, Mark L. Hanke, Ouwen Huang et al. · mBio · 2015 · 178 citations · Full text

Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular

Jason H. Melehani, David B. A. James, Ashley Dumont et al. · PLoS Pathogens · 2015 · 128 citations · Full text

Microbial Pathogens, Innate Immune System, Immunology +25

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

Lucy K. Shewell, Richard M. Harvey, M.A. Higgins et al. · Proceedings of the National Academy of Sciences · 2014 · 114 citations · Full text

Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and Modes of Action

Isaac Thomsen, Gopal Sapparapu, David B. A. James et al. · The Journal of Infectious Diseases · 2017 · 87 citations · Full text

Microbial Pathogens, Toxin Neutralization, Humoral Response +17

All major cholesterol-dependent cytolysins use glycans as cellular receptors

Lucy K. Shewell, Christopher J. Day, Freda E.‐C. Jen et al. · Science Advances · 2020 · 67 citations · Full text