Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin

Tyler D. Scherr, Mark L. Hanke, Ouwen Huang, +6

mBio

Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular

Jason H. Melehani, David B. A. James, Ashley Dumont, +2

PLoS Pathogens

Microbial PathogensInnate Immune SystemImmunologyImmune RegulationCell Death +23

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

Lucy K. Shewell, Richard M. Harvey, M.A. Higgins, +11

Proceedings of the National Academy of Sciences

Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and Modes of Action

Isaac Thomsen, Gopal Sapparapu, David B. A. James, +10

The Journal of Infectious Diseases

Microbial PathogensToxin NeutralizationHumoral ResponseImmunologyPathology +15

All major cholesterol-dependent cytolysins use glycans as cellular receptors

Lucy K. Shewell, Christopher J. Day, Freda E.‐C. Jen, +17

Science Advances

Identification of a Crucial Residue Required for Staphylococcus aureus LukAB Cytotoxicity and Receptor Recognition

Ashley Dumont, Pauline Yoong, Xiang Liu, +8

Infection and Immunity

Drug TargetToxinologyMicrobial PathogensImmunologyMolecular Biology +22

Children with Invasive Staphylococcus aureus Disease Exhibit a Potently Neutralizing Antibody Response to the Cytotoxin LukAB

Isaac Thomsen, Ashley Dumont, David B. A. James, +5

Infection and Immunity

Microbial PathogensKlebsiella PneumoniaeImmunologyStaphylococcus AureusS. Aureus Antigens +14

Biochemical Activities of Streptococcus pneumoniae Serotype 2 Capsular Glycosyltransferases and Significance of Suppressor Mutations Affecting the Initiating Glycosyltransferase Cps2E

David B. A. James, Kanupriya Gupta, Jocelyn R. Hauser, +1

Journal of Bacteriology

Cps SynthesisBiosynthesisEngineeringBiochemistryMedicine +13

The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function

Stephen W. Tuffs, David B. A. James, Jovanka Bestebroer, +10

PLoS Pathogens

Microbial PathogensLung InflammationInnate Immune SystemImmunologyImmune Regulation +24

Genetic and Biochemical Characterizations of Enzymes Involved in Streptococcus pneumoniae Serotype 2 Capsule Synthesis Demonstrate that Cps2T (WchF) Catalyzes the Committed Step by Addition of β1-4 Rhamnose, the Second Sugar Residue in the Repeat Unit

David B. A. James, Janet Yother

Journal of Bacteriology

EngineeringGlycobiologyEnzymes InvolvedGlycoproteomicsBiosynthesis +17