Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

Nicolas Aznar, Krishna Midde, Ying Dunkel, +12

eLife

Wnt SignalingNovel Non-receptor GefCancer BiologyTumor BiologySignaling Pathway +16

GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis

Inmaculada López-Sánchez, Ying Dunkel, Yoon-Seok Roh, +11

Nature Communications

FibrosisSignal TransductionHepatologyLiver FibrosisSignaling Pathway +12

Host engulfment pathway controls inflammation in inflammatory bowel disease

Ibrahim M. Sayed, Katherine Suarez, Eileen Lim, +13

FEBS Journal

InflammationChronic Inflammatory DiseasesAutoimmune DiseaseImmunologyElmo1-depleted Edms +13

AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

Nicolas Aznar, Arjun Patel, C.C. Rohena, +6

eLife

CytoskeletonCellular PhysiologyTumor BiologySignaling PathwayCell Regulation +19

STAT3 Protein Up-regulates Gα-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis

Ying Dunkel, Andrew Ong, Dimple Notani, +4

Journal of Biological Chemistry

ImmunologyCancer BiologyCellular PhysiologyTumor BiologyPositive Feedback Loop +16

Prognostic Impact of Modulators of G proteins in Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer

Jorge Barbazán, Ying Dunkel, Hongying Li, +4

Scientific Reports

Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors

S. Gary, Nicolas Aznar, Nicholas A. Kalogriopoulos, +6

Proceedings of the National Academy of Sciences

Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple

Nicolas Aznar, Jason Ear, Ying Dunkel, +9

Science Signaling

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin

Nicolas Aznar, Nina Sun, Ying Dunkel, +3

Molecular Biology of the Cell

Tumor BiologySignal TransductionSignaling PathwayCell RegulationNatural Sciences +11

Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors

Jason Ear, Ying Dunkel, Yash Mittal, +9

Scientific Reports