Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

Nolan J. Hoffman, Benjamin L. Parker, Rima Chaudhuri, +15

Cell Metabolism

MechanobiologyMuscle FunctionSignal TransductionSkeletal MuscleGlobal Phosphoproteomic Analysis +9

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

Sean J. Humphrey, Guang Yang, Pengyi Yang, +4

Cell Metabolism

Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking

Mark Larance, Georg Ramm, Jacqueline Stöckli, +8

Journal of Biological Chemistry

Protein FunctionMolecular PhysiologySignal TransductionBiochemistryGlut4 Storage Vesicles +12

A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets

Zhipeng Li, Ryan J. Schulze, Shaun G. Weller, +8

Science Advances

MitophagyLipid DropletsLipid MovementAutophagic DigestionCell Autophagy +14

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

Daniel J. Fazakerley, Annabel Y. Minard, James R. Krycer, +10

Journal of Biological Chemistry

Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects

Katherine Tonks, Yi Zhen Ng, Samantha Miller, +13

Diabetologia

Muscle FunctionInsulin SignalingCellular PhysiologyMetabolic SyndromeSkeletal Muscle +14

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes

Annabel Y. Minard, Shi‐Xiong Tan, Pengyi Yang, +7

Cell Reports

Metabolic DisorderSignaling NetworkMajor Regulatory NodeMetabolic RemodelingInsulin Signaling +20

Selective Insulin Resistance in Adipocytes

Shi‐Xiong Tan, Kelsey H. Fisher‐Wellman, Daniel J. Fazakerley, +7

Journal of Biological Chemistry

ObesityInsulin ResistanceMetabolic SyndromeSelective Insulin ResistanceBiochemistry +7

High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

James G. Burchfield, Melkam A. Kebede, Christopher C. Meoli, +22

Journal of Biological Chemistry

Kinetic Evidence for Unique Regulation of GLUT4 Trafficking by Insulin and AMP-activated Protein Kinase Activators in L6 Myotubes

Daniel J. Fazakerley, Geoffrey D. Holman, Anna E. Marley, +3

Journal of Biological Chemistry